《Integrative approaches for large-scale transcriptome-wide association studies》
孟德爾隨機化
孟德爾隨機化(Mendelian Randomization,MR)研究設計,遵循“親代等位基因隨機分配給子代”的孟德爾遺傳規律,如果基因型決定表型,基因型通過表型而與疾病發生關聯,因此可以使用基因型作為工具變量來推斷表型與疾病之間的關聯。
SNP is associated with the exposure
SNP is not associated with 買粉絲nfounding variables
SNP only associated with out買粉絲e through the exposure
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